Tuesday, June 24, 2008

sample result interpretation

http://www.orchidcellmark.com/dnatestresources/resultsinterpretation/


EXAMPLE OF INCLUSION RESULT

System Mother Child Alleged Father Paternity Index
D3S1358 14 , 18 14, 15 15 , 16 4.03
vWA 14 , 17 14 , 17 14 , 17 2.72
FGA 18 , 24 18 , 22 22 , 24 2.81
D8S1179 13 13 , 14 11 , 14 1.49
D21S11 31.2 , 33.2 30 , 31.2 30 3.88
D18S51 14 14 14 , 17 2.94
D16S539 9 , 12 9 , 11 11 , 12 1.57
TH01 7 , 9.3 7 , 9.3 7 , 9.3 1.41
D2S1338 19 , 24 19 , 24 19 , 23 1.89
D19S433 13 , 14 14 , 17.2 13 , 17.2 39.00

  1. Identify the two alleles (numbers) for the child at each system. (e.g. the child has a 14, 15 at system D3S1358)
  2. Determine which of the child’s alleles came from the mother. (e.g. at system D3S1358, the mother (14,18) gives the child (14,15) a 14)
  3. Therefore the alleged father must provide the child with the other allele, a 15. (e.g. at system D3S1358, the alleged father (15,16) provides the child (14,15) with the 15)
  4. This matching between the child and alleged father at system D3S1358 is an example of an inclusion.
  5. Once the alleles are analyzed for all systems, population statistics are then calculated based upon the paternal alleles provided to the child. The result is a Paternity Index for each system.
  6. The final calculation involves the multiplication of each Paternity Index with the others to come up with a Combined Paternity Index value. For example, the Paternity Index of system D3S1358 is 4.03 and the Combined Paternity Index for the overall results is 85,426 to 1.

EXAMPLE OF EXCLUSION RESULT

System Mother Child Alleged Father Paternity Index
D3S1358 14 , 18 14 , 15 17 , 18 0.00
vWA 14 , 17 14 , 17 14 , 20 2.72
FGA 18 , 24 18 , 22 23 , 25 0.00
D8S1179 13 13 , 14 8 , 14 1.49
D21S11 31.2 , 33.2 30 , 31.2 30 , 35 3.88
D18S51 14 14 15 , 18 0.00
D16S539 9 , 12 9 , 11 11 , 15 1.57
TH01 7 , 9.3 7 , 9.3 6 , 9.3 1.41
D2S1338 19 , 24 19 , 24 19 , 20 1.89
D19S433 13 , 14 14 , 17.2 15 , 16 0.00


  1. Identify the two alleles (numbers) for the child. (e.g. the child has a 14, 15 at system D3S1358)
  2. Determine which of the child’s alleles came from the mother. (e.g. at system D3S1358, the mother (14,18) gives the child (14,15) a 14)
  3. Therefore the biological father must provide the child with the other allele, a 15. However the tested alleged father is a 17,18 and could not have provided the child with a 15.
  4. This mis-match between the child and alleged father at system D3S1358 is an example of an exclusion and the paternity index is 0.00 for this system.
  5. If the child and alleged father do match, population statistics are used to derive a paternity index for that system.
  6. When the statistical calculations are applied to the all of the paternity index results in the above case, the Combined Paternity Index is 0.00 and therefore there is a 0% probability of paternity.

** A Combined Paternity of Index of 100 to 1 is required by aaBB Accreditation Standards to report an Inclusion.

** At least 2 Exclusion Systems must be found by aaBB Accreditation Standards to report an Exclusion.

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1 comment:

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